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C1897
Sigma
Catechol-O-methyl Transferase from porcine liver
lyophilized powder, ≥150 units/mg protein
| Synonym: | COMT, Pyrocatechol-O-methyl Transferase, S-Adenosyl- |
| CAS Number: | 9012-25-3 |
| Enzyme Commission (EC) Number: | 2.1.1.6 ( BRENDA | IUBMB ) |
| EC Number: | 232-727-6 |
| MDL number: | MFCD00081488 |
Description
| Biochem/physiol Actions | Major degradative enzyme for catecholamine neurotransmitters; methylates the o-hydroxyl group |
| Unit Definition | One unit will produce 1.0 nanomole of total O-methylated products from 3,4 dihydroxyacetophenone per hour at pH 7.6 at 37 °C. Previous radioactive assay unit definition: One unit will catalyze the methylation of 1.0 nanomole of protocatechuic acid per hr at pH 7.9 at 37°C using S-adenosyl- |
| Physical form | Lyophilized powder containing phosphate buffer and dithiothreitol |
Properties
| form | lyophilized powder |
| purified by | chromatography |
| composition | Protein, ~50% biuret |
| storage temp. | −20°C |
Safety
| Personal Protective Equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
| WGK Germany | 3 |
